HPLC Maintenance Checklist: What to Monitor During Periodic Service
Periodic maintenance checklist and expert tips to prevent performance loss on Thermo Scientific HPLC systems.
HPLC systems carry a large share of daily analytical workload in laboratories. Performance loss, repeatability issues and unexpected failures often stem from insufficient preventive maintenance.
Pump and Fluid Path Checks
- Pump seal wear condition
- Mobile phase filter replacement
- Leak test and pressure stability measurement
- Injector needle and rotor seal inspection
Detector and Data Quality
For UV detectors, lamp life tracking, signal noise and baseline stability should be monitored regularly. Abnormal fluctuations are critical indicators for early intervention.
Performance Qualification (PQ)
PQ tests aligned with OEM procedures verify that system suitability criteria are met. In GMP environments, these records are required during audits.
When Professional Service Is Needed
Pressure fluctuations, non-reproducible peak areas or autosampler errors warrant on-site diagnosis. Stella Lab Tech offers contract maintenance plans for your Thermo Scientific HPLC fleet.
Learn more about our HPLC service.
